Mycobacterial Disease Attributable to Tumor Necrosis Factor–α Blockers

Tumor-necrosis-factor blockers: differential effects on mycobacterial immunity.

BACKGROUND Tumor necrosis factor (TNF) plays a pathogenic role in rheumatoid arthritis but is essential for antimycobacterial host defenses. The risk of reactivation of latent Mycobacterium tuberculosis infection is greater with the TNF monoclonal antibody infliximab than with the soluble TNF receptor etanercept. The basis of this difference is not known. METHODS The effects that the monoclon...

Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis.

Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the pathogenesis of rheumatoid arthritis and other autoimmune diseases. Three TNF-alpha-suppressing drugs have been approved to treat selected autoimmune diseases; 2 are monoclonal antibodies against TNF-al...

Induction of systemic lupus erythematosus with tumor necrosis factor blockers.

Making tumor necrosis factor blockers safer: a prescriber's consumptive challenge.

Predictors of response to tumor necrosis factor-alpha blockers in ankylosing spondylitis.